"These results imply that the exposure to e-cigarette vapor may initiate the fibrotic process in people who do not have lung fibrosis, and that the exposure to e-cigarette vapor in patients with lung fibrosis may worsen the outcomes," said Nho.
Can vaping cause popcorn lung?
Recently, pulmonologists Catherine Bonham, MD, and Tessy Paul, MD, explained the origins of popcorn lung, now a complication of vaping. Popcorn lung (bronchiolitis obliterans) belongs to a family of lung diseases called interstitial lung diseases (ILD) .
Can vaping cause lung injuries?
Vaping is known to cause lung tissue injuries. While the study was not designed to uncover the mechanisms behind the serious lung injuries and deaths that have been linked with vaping, the findings shed light on how e-cigarettes may affect the crucial cell type that repairs lung injuries when they occur.
Do e-cigarettes cause lung fibrosis?
"Our study further supports the concept that the use of e-cigarettes is not safer than smoking conventional cigarettes and that vaping is a potential risk factor to promote lung fibrosis." Nho was scheduled to present the research at the American Society for Investigative Pathology annual meeting in San Diego this month.
Does e-cigarette or vaping use affect lung function in adolescents?
Carroll BJ, et al. Impaired lung function following e-cigarette or vaping product use associated lung injury in the first cohort of hospitalized adolescents. Pediatr Pulmonol.
What is the gas you inhale when you vape?
Is smoking cigarettes bad for you?
Is lung fibrosis fatal?
Is vaping better than smoking?
Doctors Spot a New, Severe Lung Illness Tied to Vaping
The report was published Nov. 21 in the journal CMAJ.. In the United States, the number of those stricken with a severe lung illness tied to vaping has reached 2,172, according to the U.S. Centers ...
Can vaping scar your lungs? New insights and a possible remedy
Researchers report evidence that the compounds in e-cigarette liquid could potentially cause the body's tissue repair process to go haywire and lead to scarring inside the lungs. The new study ...
Can vaping scar your lungs? New insights and | EurekAlert!
Researchers report evidence that the compounds in e-cigarette liquid could potentially cause the body's tissue repair process to go haywire and lead to scarring inside the lungs. The new study ...
Vaping-related lung injury - PMC
The use of electronic nicotine delivery systems has increased in popularity dramatically over the past decade. Although lung diseases caused by vaping have been reported since the modern invention of the electronic cigarette, in the summer of 2019, patients began to present to health care centers at epidemic levels with an acute respiratory illness relating to vaping, which the Center for ...
Is vaping bad for you?
Unless you have turned off all your electronic devices, stopped reading the newspaper and have no functioning television then you have probably heard that electronic cigarettes or vaping is really bad for your health. In fact, there is a small epidemic of users of these products that are getting hospitalized with life-threatening breathing problems.
Is nicotine bad for your lungs?
It is not a big surprise to the pulmonary medicine community that inhaling nicotine and oils would be bad for your lungs. The big surprise has been how slow the federal government has been in recognizing that this is just another wolf in sheep’s clothing. Cotton candy, grape and other flavors all targeting teenagers have been so successful that the next generation of nicotine addicts has been hatched. 25% of teenagers report using electronic cigarettes before they leave high school.
Do fibroblasts die from nicotine?
The researchers then experimented with e-liquids containing different amounts of nicotine, an active component of e-cigarettes. In those studies, fibroblasts exposed to nicotine-free e-liquids underwent cell death while those exposed to nicotine-containing e-liquids showed increased viability, with higher concentrations of nicotine leading to a greater increase in viability. These cells also super-charged their expression of a protein that binds to nicotine, called the alpha 7-nicotinic acetylcholine receptor.
Does vaping help with fibrosis?
They found that when fibroblasts were exposed to e-cigarette aerosol extract, they were significantly more viable than those exposed to smoke extracts, suggesting that vaping— to a greater extent than tobacco smoking—could contribute to fibrosis by helping fibroblasts stay alive for an abnormally long time.
Does nicotine affect fibroblasts?
Because the overactive fibroblasts were found to also increase the expression of a certain nicotinic receptor, Nho said finding a way to inhibit the pathological functions of the receptor that is abnormally regulated by nicotine in e-cigarettes could help to de-activate the fibroblasts and reduce scar formation. Further research can help to test this idea and determine whether different e-cigarette brands or components have different effects on fibroblast activity.
Do fibroblasts die off?
In normal conditions, fibroblasts activate and proliferate when they are needed to heal a wound and then die off when no longer needed. In the case of lung fibrosis, fibroblasts become overactivated and then fail to die off, leading to a damaging buildup of scar tissue.
Does inhibiting nicotinic receptors slow scar formation?
The new study, conducted in cell cultures, also suggests that inhibiting a certain nicotinic receptor could help promote the death of overactive fibroblast cells and thus slow scar formation, called fibrosis, in affected individuals.
Does vaping cause lung damage?
Vaping is known to cause lung tissue injuries. While the study was not designed to uncover the mechanisms behind the serious lung injuries and deaths that have been linked with vaping, the findings shed light on how e-cigarettes may affect the crucial cell type that repairs lung injuries when they occur.
Can nicotine cause scarring?
Taken together, these findings suggest that e-cigarettes containing nicotine can potentially cause lung fibroblasts to become overactive and ultimately create scarring. The results further suggest this can happen both in healthy people and in people whose fibroblasts already have a tendency to grow out of control, such as those with idiopathic pulmonary fibrosis.
What is an end vape?
ENDS, also known as E-cigarettes and vaping devices, were originally developed as a replacement device for conventional tobacco cigarette smokers [1]. However, their success in the arena of smoking cessation has been very limited, and they remain unapproved as cessation tools due to a lack of data demonstrating efficacy relative to currently approved nicotine replacement therapies [2]. The aerosols produced by E-cigarettes are known to cause a variety of deleterious health effects, although more research and long-term studies are still needed [2]. E-devices have rapidly evolved since entering the international market in 2013, with vape pens, box mods, and pod-based devices being the most commonly used vaping devices in 2020 [3]. Although E-cigarettes are used in conjunction with conventional tobacco by many cigarette smokers (dual users), their sole use in young adults and adolescents has skyrocketed [4]. This is concerning as use of tobacco products had been declining worldwide for over 50 years, and now, a new generation of nicotine addicts is being created through these novel vaping devices through the use of appealing flavors and packaging [5]. Even more concerning is that children and teenagers who use E-cigarettes are more likely to smoke conventional tobacco [6].
What is the difference between evali and lipoid pneumonia?
a, bThe histologic distinction between exogenous lipoid pneumonia and electronic cigarette or vaping-associated lung injury (EVALI) is dramatic and distinctive. Exogenous lipoid pneumonia shows numerous lipid vacuoles a, most of which are much larger than individual cells. There is associated fibrosis in which many of the droplets are embedded. Occasional macrophages contain lipid droplets within their cytoplasm. However, the droplets are much larger and more variable (arrow) compared to EVALI, H&E, × 100. Larger lipid vacuoles are surrounded by several multinucleated giant cells and a foreign body giant cell reaction (arrowhead) b, a feature not seen in EVALI, H&E, × 200
Is vaping a lung disease?
Although lung diseases caused by vaping have been reported since the modern invention of the electronic cigarette , in the summer of 2019, patients began to present to health care centers at epidemic levels with an acute respiratory illness relating to vaping, which the Center for Disease Control termed E-cigarette or vaping product use-associated lung injury (EVALI). This review discusses electronic nicotine delivery systems as well as the etiology, clinical presentation, imaging findings, pathologic features, treatment, and long-term consequences of EVALI. We conclude with the practical impact EVALI has had on the practice of pathology.
Is vaping a respiratory disease?
In the summer of 2019, an acute, mysterious, and deadly respiratory illness related to vaping emerged, primarily in young patients, in the USA. Cases increased dramatically and peaked in late September 2019. The Center for Disease Control and Prevention (CDC) termed the disease causing this epidemic E-cigarette or vaping product use-associated lung injury (EVALI). Prior to EVALI, vaping had been associated with a variety of different pulmonary presentations ranging from lipoid pneumonia to diffuse alveolar hemorrhage, but at low numbers. In this review, we discuss electronic nicotine delivery systems (ENDS) as well as the etiology, clinical presentation, imaging findings, pathologic features, treatment, and long-term consequences of EVALI. We conclude with a discussion on the practical impact EVALI has had on the practice of pathology.
What is the lung injury from vaping?
A 17-year-old boy may well be the first case of a novel type of lung injury from vaping. The condition is similar to "popcorn lung," which is seen in workers exposed to the chemical flavoring diacetyl, an ingredient used to produce microwave popcorn, researchers said. When inhaled, the chemical causes inflammation and obstruction ...
What is the chemical that causes lung damage?
The CDC noted that more than 85% of cases involved products that contained THC. Experts said an oily chemical known as vitamin E acetate appears to be involved, which is used in a variety of products, but when heated and inhaled it can cause severe lung damage.
What happens when you inhale a chemical?
When inhaled, the chemical causes inflammation and obstruction of the small airways in the lungs.
Can you swallow a vapor of a vapor?
While these compounds may be safe to swallow, they can become toxic and cause lung damage when they're heated and inhaled as a vapor, he said.
Did Trump ban e-cigarettes?
In September, President Donald Trump pledged to ban sale of most flavored e-cigarettes in the United States . But the New York Times reported this week that under pressure from lobbyists and political advisers, Trump has not yet taken action, saying only that he wants to study the issue.
Is vaping bad for you?
Vaping has health risks and the potential short and long-term effects of vaping remain unknown, Bosma said. Nonsmokers, pregnant women and young people should not vape, she cautioned. "The patient, his family and his health care team want to use his case as a warning to others," Bosma said.
What is the most dangerous material for pulmonary fibrosis?
Some of the known materials with potential risk: Mold, metal dust, silica, asbestos, chemical s in food flavoring.
What is popcorn lung?
Popcorn lung (bronchiolitis obliterans) belongs to a family of lung diseases called interstitial lung diseases (ILD) . While you may not have heard of even the most common ILD, pulmonary fibrosis, Bonham says, “it’s one of the more common reasons we do lung transplants.”.
Can you cure pulmonary fibrosis from a pet bird?
Eliminating exposure isn’t always a cure. For example, some people with pet birds develop pulmonary fibrosis from the feathers and dander. They get rid of their birds, but afterward, a few still see disease progression. That is, the scar tissue continues to build.
Is it worth working with pulmonary fibrosis patients?
Still, despite the challenges, working with pulmonary fibrosis patients feels worthwhile to Paul. “It’s nice to take care of patients who others aren’t comfortable taking care of. They need someone; it’s nice to be that someone.”
Can immunosuppressants slow scar formation?
The options are limited. In some cases, anti-inflammatory steroids and immunosuppressants can slow or even stop the creation of new scars.
Is pulmonary fibrosis a scarring disease?
While distinct diseases, Bonham points out that in all types of pulmonary fibrosis, “there’s been injury to the lung, and then there’s an ongoing process of scarring. It’s just that lot of different things can lead up to it.”
Does smoking cigarettes clear mucus?
It’s already established that tobacco smoke from regular cigarettes makes it hard for the airways to clear phlegm and mucus from the lungs. Building on their previous work in the field, the team of researchers from the University of Kansas, University of Miami, and Mt. Sinai Medical Center in Miami Beach shows in the study ...
Is vaping sticky?
This research shows that, at least when it comes to the body’s ability to clear mucus and phlegm, one of the consequences of vaping and smoking traditional cigarettes is equally sticky.
Is vaping safer than smoking cigarettes?
Despite numerous studies pointing out the health consequences of vaping, it still remains popular, in part because people believe it’s safer than smoking cigarettes and therefore makes a good smoking alternative or smoking cessation tool. This research shows that, at least when it comes to the body’s ability to clear mucus and phlegm, one of the consequences of vaping and smoking traditional cigarettes is equally sticky.
Is vaping bad for you?
The science community has not done the vaping industry any favors by discovering the many ills associated with e-cigarettes . Adding to a growing list of health concerns that includes wheezing, heart disease, and popcorn lung, scientists publishing in the American Journal of Respiratory and Critical Care Medicine on Friday reveal a new consequence of vaping: even stickier phlegm and mucus.
Does smoking cigarettes make it harder to breathe?
It’s already established that tobacco smoke from regular cigarettes makes it hard for the airways to clear phlegm and mucus from the lungs. Building on their previous work in the field, the team of researchers from the University of Kansas, University of Miami, and Mt. Sinai Medical Center in Miami Beach shows in the study that the same goes for the vapor from e-cigarettes, which contains the same airway-impairing agent that’s found in tobacco smoke: nicotine.
Does e-cigarette vapor cause mucociliary dysfunction?
As the team found in the lung cells of humans and sheep, the answer is a resounding yes. The nicotine from e-cigarette vapor is associated with mucociliary dysfunction. Unsplash / Nery Zarate. The body naturally produces mucus and phlegm, but it also naturally clears it.
What is the gas you inhale when you vape?
The gas you inhale when you vape is known as oxygen . There is added vg or pg, flavoring and nicotine. I don't see it causing a disease, I have only seen it benefit people. Just my 2 cents!
Is smoking cigarettes bad for you?
When you smoke cigarettes you are burning a solid, removing oxygen and replacing it with heated, dry, carbon dioxide and hundreds if not thousands of carcinogens that are known to have serious side effects. The end result will eventually be asthma, emphysema, chronic obstructive pulmonary disease just to name a few. I have seen the long terms effect of smoking... very very bad...
Is lung fibrosis fatal?
Pulmonary fibrosis is a fatal, incurable lung disease in which the lung tissue hardens and ceases to transfer oxygen into the blood. It is assumed to be a kind of autoimmune reaction, triggered by inhaled particles (such as coal dust, metal dust, asbestos but also pesticides and detergents). It is a rare condition, but former smokers frequently exposed to the kinds of particles have an elevated risk of contracting it.
Is vaping better than smoking?
Off the top of my head, vapor (a liquid) contains far less particulates than smoke (a solid), neither will be as good for you as fresh clean mountain air but for most of us the choice is between vaping and smoking.
